The radiation stability of a number of materials commonly used in sterile packaging of medical and pharmaceutical products was discussed during the webinar. Where can I find this information for other materials, such as PVDF and polycarbonate?
A number of reference documents were highlighted during that webinar that bear mentioning again.
These documents, and others, provide helpful guidance related to the effect of sterilization on materials, as part of a fuller discussion of sterilization processes and considerations. According to these references, polycarbonate is considered to be radiation-stable, owing to the aromatic nature of the chemical structure (contain conjugated planar ring systems with delocalised pi electron clouds). Some grades may undergo discoloration, although significant strides have been made by resin and additive producers to minimize, mitigate, or eliminate this effect. Fluoropolymers, like PTFE and PCTFE, are known to be unstable to radiation sterilization. Other fluoropolymers (such as PVDF) are more stable to radiation sterilization, although, as always, product validation and verification are expected over the intended shelf-life.